The molecular mechanism of action of methylthioinosinedicarboxaldehyde on ribonuclease A as a model system.
نویسندگان
چکیده
The molecular mechanism of action of the antitumor drug, methylthioinosine periodate oxidation product, was demon strated. This periodate oxidation product (methylthioinosinedicarboxaldehyde) inhibited bovine pancreatic ribonuclease A. The inhibition was due to Schiffs base formation with e-amino groups of lysine residues, one of which was in close proximity to the catalytic center of the enzyme.
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ورودعنوان ژورنال:
- Cancer research
دوره 33 4 شماره
صفحات -
تاریخ انتشار 1973